Big Mouth Season 5 Cast: Here Are the All-Big Names Voicing Characters!

Season 5 of Big Mouth will reunite Bridgeton's horniest teenagers for even more melodrama and big emotions. Nick Kroll as Nick Birch/Maury the Hormone Monster (and more), John Mulaney as Andrew Glouberman.

Jessi Klein as Jessi Glaser, Jason Mantzoukas as Jay Bilzerian, Andrew Rannells as Matthew MacDell, and Maya Rudolph as Connie the Hormone Monstress are all set to return for the Netflix animated series.

Ayo Edebiri will also reprise her role as Missy Foreman-Greenwald, which she began near the end of Season 4 after Jenny Slate chose to step down in 2020. “At the start of the show.

I reasoned that I could play ‘Missy' because her mother is Jewish and White — as am I,” Slate wrote in an Instagram post at the time. “However, ‘Missy' is also Black, and People of color should play black characters on an animated show.”

Season 5 will also appear to highlight Ali (Ali Wong), a pansexual student first introduced in Season 3, as well as introduce several new characters. It will include new creatures called lovebugs, which can transform into hate worms depending on the kids' emotional state.

This is intended to set up Big Mouth's upcoming spinoff Human Resources, which will delve into the “far more adult” world of the creatures the kids have met in the original series, such as the Shame Wizard and Depression Kitty, Hormone Monsters, and others.

Learn more about the Season 5 cast members below.

Brandon Kyle Goodman Voices Walter

Nick's lovebug Walter, played by Goodman, encourages him to pursue his crush on Jessi. When this backfires, and Jessi publicly rejects Nick, Walter mutates into a hateworm.

Big Mouth Season 5 Cast

Goodman joins the cast of Big Mouth after serving as a writer on the show since Season 4. The actor appeared in the Netflix film Feel the Beat in 2020, and he will continue to play Walter as a main cast member in Human Resources.

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Keke Palmer Voices Rochelle

Palmer plays Missy's hater Rochelle, who sends Missy on a rage-filled rampage after Jessi and Ali grow closer and co-opt Missy's affinity group.

Big Mouth Season 5 Cast

Palmer has a lengthy filmography, but her most recent credits include the film Hustlers and Season 3 of the television series Scream.

She also co-hosts the daytime news show Strahan, Sara, and Keke. Rochelle will continue to be voiced by her as a series regular on Human Resources.

Sonya is Voiced by Pamela Adlon

Sonya, Jessi's lovebug, is voiced by Adlon and appears when Jessi begins to wonder if her feelings for her classmate Ali are more than friendly.

Big Mouth Season 5 Cast

Adlon's impressive resume includes starring roles on Californication, Louie, and Better Things, as well as her Emmy-winning performance as Bobby on King of the Hill. She will return to Human Resources as Sonya as a guest star.

Adam Scott Voices Mr. Keating

Big Mouth Season 5 Cast

Scott is best known for his roles in Parks and Recreation, Big Little Lies, and The Good Place. He's also appeared in a number of films, including Step Brothers and Hot Tub Time Machine 2, and will appear in the upcoming Apple TV+ series Severance.

Simon Sex is Voiced by Jemaine Clement

Big Mouth Season 5 Cast

The New Zealander is best known as one-half of the renowned comedy duo Flight of the Concords. Clement's voice acting credits include Despicable Me, Rio, Moana, and The Lego Batman Movie. He was most recently a cast member on the FX series Legion, and he will appear in the upcoming films Avatar 2 and Avatar 3.

Kristen Schaal Voices Bernie

Big Mouth Season 5 Cast

Schaal has done a lot of voice acting, including roles on shows like Bob's Burgers, Gravity Falls, and Bojack Horseman. She has also appeared as a recurring commentator on The Daily Show, as well as in 30 Rock, The Last Man on Earth, and HBO's Flight of the Conchords.

Chloe Fineman Voices Leah

Big Mouth Season 5 Cast

Fineman, who has been a cast member on Saturday Night Live since 2019, is still in her early career. She'll be seen in the upcoming movies Father of the Bride and Babylon.

Kumail Nanjiani Voices Himself

Big Mouth Season 5 Cast

Kumail Nanjiani is an actor-director best known for his work on the television shows Silicon Valley and Franklin & Bash, as well as his roles in the films The Lovebirds, The Big Sick, and Eternals. His credits as a voice actor include roles in Adventure Time and Bless the Harts.